Research Finds Link Between Supercentarians Cytotoxic T-cells Througha single-cell RNA analysis, Scientists from the RIKEN Center for Integrative Medical Science (IMS) in Japan have found that people over the age of 110 have an excess of a type of immune cell called cytoxic CD4 T-cells. The study's authors explained: "This research shows how single-cell transcription analysis can help us to understand how individuals are more or less susceptible to diseases. CD4-positive cells generally work by generating cytokines, while CD8-positive cells are cytotoxic, and it may be that the combination of these two features allows these individuals to be especially healthy."
Leukemia Cells Become Non-Cancerous through Epigentic Changes
Researchers from Josep Carrera Leukemia Research Institute in Barcelona have discovered the ability of leukemic cells to transform into non-cancerous cells through epigenetic changes. Through a cellular model of lymphoblastic leukaemia B cells, the cells were transformed into macrophages, allowing the researchers to obtain a high-resolution epigenetic profile of each step of the transdifferentiation process. The study suggested that if the epigenetic changes identified were blocked, "leukaemia cells could not select the transdifferentiation strategy to escape from the anti-tumor effect of the drug, and the therapy would be more effective."
Vaping Illnesses Linked to Vitamin E Acetate
The CDC recently identified Vitamin E acetate as the likely culprit in the cause of the recent outbreak in lung injuries related to vaping. The new report is based upon samples taken from the lungs of 29 patients, and according to Dr. Anne Schuchat, principal deputy director of the Centers for Disease Control and Prevention “provided evidence of vitamin E acetate at the primary site of injury in the lungs.” To date, the outbreak has killed 40 people and caused illness within 2,051.
New Methodology Provides Insight into Drug Interactions
Researchers from the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences have developed a novel methodology framework that precisely identifies and characterizes how drugs influence each other when combinedduring treatments. The analysis covered over 30,000 drug pairs applied to cell lines and identified 1,832 interactions between 242 different drugs. The researchers explained: "We developed a completely new methodology to classify drug interactions. [This] methodology is able to distinguish 12 distinct interactions types and also reveals the direction of an interaction."
Tune in to hear one of our latest conversations with Dr. Susan Murrmann-- an obstetrician-gynecologist and co-founder of an all-female women's clinic Germantown, Tennessee.
"Anti-aging, or regenerative, medicine actually works towards managing and correcting underlying factors that cause disease issues rather than just place a bandage over the problem. [...] Anti-aging medicine really allows us, as practioners, to accomplish why we actually went into medicine".
A growing body of research demonstrates significant discoveries and advancements in knowledge into potential biomedical strategies for reversing the aging process. Today, researchers continue to study animal and human abilities to regenerate cells, aiming to diminish cognitive decline, immune system weakening, and other adverse effects of the biological aging process.
